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KMID : 0043320190420030274
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Archives of Pharmacal Research
2019 Volume.42 No. 3 p.274 ~ p.283
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Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3
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Yeo In-Jun
Park Ju-Ho
Jang Jun-Sung
Lee Do-Yeon
Park Jung-Eun
Choi Ye-Eun
Joo Jung-Hun
Song Joo-Kyung
Jeon Hyung-Ok
Hong Jin-Tae
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Abstract
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Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has been reported to inhibit inflammation. Carnosol, a major component of Rosemary, has prominent anti-inflammatory effects. However, its protective effect on UVB-induced inflammatory skin responses has not yet been reported. Here, we investigated the effectiveness of carnosol on UVB-induced inflammation. We examined the anti-inflammation effect of topical application of carnosol (0.05 μg/cm2) on UVB (540 mJ/cm2, for 3 successive days)-induced skin inflammation in HR1 mice. Topical application of carnosol inhibited UVB-induced erythema, epidermal thickness, inflammatory responses in HR1 mice. Carnosol reduced the level of Immunoglobulin-E and IL-1β in blood serum of UVB-induced mice. Carnosol also significantly inhibited the UVB-induced expression of inflammatory marker protein (iNOS and COX-2) in back skin of mice. In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes. Our study suggested that carnosol has protective effects on skin inflammatory skin damages by UVB.
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KEYWORD
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Carnosol, Dermatitis, STAT3, UVB
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